Excel heads! help please

I have two columns (A and B).  Column A gives the date an event starts.  Column B gives the time an event starts.

I then have two further columns (C and D) Column C gives the date an event finishes.  Column D gives the time an event finishes.

In column E I want a formula for the total duration of the event....

I can't work out how to do this.  Would anyone help? (looks at Clubbers et al)

Please :)