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there won't be any humans around in 1000 years time

the exploitation of the environment and species we share the planet with will be considered as shocking as slavery and genocide seems to us now (if we dont come to see it that way we will not survive that long anyway)

There are billions of us. You could wipe out most of us but you'd only need a few hundred to get the species going again. We're soon getting to the point where embryos can be stored indefinitely and activated again by robots when the world regenerates after the great nuclear winter. AI robots like HAL can take us into space. 

There will definitely be humans around in 1000 years. Possibly not as many with a different geographical and racial distribution, but still here.

To pretend otherwise is ludicrous

We have been on this planet 300,000 years including through ice ages and much tougher and more challenging conditions than what's ahead

AI* robots like HAL can take us into space. 

*I meant artificial Intelligence not Artificial Insemination FAOD  

My guess is that our times will be seen as characterised by a lack of purpose due to the demise of grand unifying narratives.

I reckon the worst thing to happen in the next 1000 years

Will be something no one is even thinking or writing about now

Humans will have all died because of vaccines.

According to some Roffers.

Gaga's paradox: How can I be thinking about something that no one is thinking about? It just blows one's mind.  

seems to me nuclear war is only a matter of time while we have such huge stockpiles - there may be a small percentage chance in any given year of nuclear war but over time that chance becomes much higher to the point of inevitability.   At some point somebody will miscalculate or a just a sheer madman will take control.

Not that that would kill off mankind but would kill off the world order as we know it.