2 more covid cases in UK
a perfectly no… 27 Feb 20 09:32
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seem to have acquired it in Italy in Tenerife

Since so many people coming out of Italy seem to have picked this up, you can assume the “400 cases” there is a substantial underestimate.

Two guys in my office flew back from Milan on Sunday night and have refused HR's instructions to work from home for a week because "they feel fine", aunts. 

This is why quarantine short of full China Wuhan style is pointless. 

Two guys in my office flew back from Milan on Sunday night and have refused HR's instructions to work from home for a week because "they feel fine", aunts. 

This is ridiculous.  Can't they be forced to? 

One of my clients has just flown back from DXB to Germany and I never spotted him setting me up for him having a C Virus scare. I think his issues are caused by my invoice rather than any virus.

I should no better with this guy but he is a good friend and has introduced me to some good clients so I don't really rely to much on him paying his bills and tbh the nuts stuff he gets upto is entertaining.

My brother flew into Treviso (for work) first thing Monday, ushered back on a flight pretty much straight on landing at the airport as the quarantine measures had kicked in.

Hes been told to work/w**k from home for a fortnight. 

Our work sent a load of lads home.

The offshore workers are loving it. They're all booking quick trips to italy so they get full paid quarantine for 2 weeks when they're meant to be on the rigs

Milan isn't itself in the lockdown zone. Government advice is only to self-isolate when you've been to N Italy outside of the lockdown zone if you have symptoms.

They are perfectly entitled to come into the office.

The death stats published in the times today note that the virus is being ageist. It is mostly resulting in deaths of the older generation:

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With coronavirus the death rate is not u-shaped. Yes, it rises sharply among the old but among those under 40 it is 0.2 per cent. Among those under ten it is zero. Once people enter their 40s the risk of death doubled for each additional decade - rising to 3.6 per cent for those in their 60s, 8 per cent in their 70s and almost 15 per cent for those over 80.

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https://www.thetimes.co.uk/edition/news/coronavirus-children-are-safer-than-anyone-0l3b5tsc6

They think this is because children's immune systems are well tuned to dealing with pathogens they have not seen before - their "innate immune" systems are stronger. Adults rely on adaptive immunity (antibodies and acquired resistance) and their innate immunity wanes.  Women tend to have stronger immune systems than men.

It will only be a few years before everyone has some degree of learned immunity to the latest coronavuvu.

If I saw anyone in my neighbourhood who I thought was peddling to local kids, I would get straight out the house and set about him.. These guys are all pussies.

One of the patients (presumably the one who has been taken to the Royal Liverpool) is from Buxton in Derbyshire and is said to have acquired the virus in Tenerife. They are a parent and their children's school is closed.

They can't be transporting people 100 miles every time there's a case. They are going to need the ability to treat this locally.

re Tenerife case, we will want to know whether s/he stayed at the hotel where the Italian doctor stayed. If not then it suggests a more general spread in Tenerife.

Difficult to believe it's not already going round in the UK tbh.

Isn't it just common sense and decency though?  It's not like the virus knows that it has to stop when it gets to the edge of the quarantine zone in northern Italy.

I tend to agree with torontochick actually. People should stick to the rules and people who are sticking to the rules should be suspected. If every man tried to be his own epidemiologist on this, society will melt down. If the rules say self isolate, do so. If they don't, no need.

There was an odd statement in the WHO briefing the other day about their trip to China where they said that they were not seeing evidence of lots of mild unreported cases. Which is worrying as we are  all praying that the denominator effect brings the ultimate fatality rate down. But the effect may not be as great as people are hoping, particularly once the lag effect has run its course. 

At Trumps presser yesterday they were talking about 2-3%. He was trying to lie that it was like the flu, but couldn’t quite do it as it was so obviously wrong.

I still think if we can control it enough so that we’re not overwhelmed and can flatten out the epi curve/spike - that it will probably come in at 1-2% in the West. Ive been pretty consistent on that for a few weeks and the increasing amounts of non China data seem to align with it - although clearly there are risks both ways.

Ofc now we are realising that containment might well not be possible, people will start to wake up to the reality of what that 1-2% base case could mean. Quite a lot of dead people (2-300,000 in the UK). To try and stop that catastrophe there is probably going to have to be lots and lots of “inconvenience” for people who object to panicky overreactions.

I think this means a recession is almost a certainty. We were pretty much on the edge of one anyway. The only question is how bad?

I agree with you as to the mortality rate of detectable cases. The number of unknown cases is inherently unknown. I don't think it means much that the WHO didn't see any evidence of inherently undetectable things on the basis of a few hours trundling round Wuhan in a jeep.

There was an odd statement in the WHO briefing the other day about their trip to China where they said that they were not seeing evidence of lots of mild unreported cases.

Yes this is concerning but was contested in one piece I read by another epidemiologist who cited the fact that there are cases "popping up" elsewhere without an obvious chain of transmission - this tends to support the idea that there are in fact mild unreported cases.

Laz the basis for the statement was that a decent amount of community testing has been done which failed to demonstrate clearly that there are a significant number of cases just hanging around not seeking medical care.

Ultimately though it has to be one of two things:

1. There are a lot of unreported cases -> current mortality figures are overestimates

2. There are few unreported cases -> containment measures have been surprisingly effective to date

"The number of unknown cases is inherently unknown"

Proper profound right there.

Puts me in mind of the old Ben Elton joke - "the government says that about x% of the adult population is carrying the HIV virus without knowing it.  How does the government know?  Shouldn't they tell them?"

Anyway, the doom mongers can't have it both ways.

Either it's mega infectious but has a lower mortality rate than is being measured, or it's more pathogenic but less infectious than thought.

Prof John. Nichols of HKU said fairly early on in the outbreak that he thought this looked like an aggressive cluster disease that, it fought aggressively, would manifest itself in intense localised bursts, and maybe, if Aylward is right, he’s right. I don’t attempt to arbitrate between public health specialists (although I wish I could and may refrain as a public health doctor, just to annoy both u guys and the coronavuvu (a new and powerful enemy for it!)). But I do note that internet chunterers tend to pick the side they agree with. So whatever I see people saying on the internet, I tend to highlight the counter-perspective.

Fair point Chimp.  So you reckon it's likely to only affect quarter of the population?

 Very hard to say - depends on both the true infectivity which remains unclear and also the public health measures taken to limit spread. We don’t have the capability to do it like China has for obvious reasons

The other thing Aylward said which was a little disquieting is the availability of ICU beds and ECMO facilities - apparently much better in China than elsewhere. This actually rings true to me, particularly the ECMO point. The use of  ECMO remains comparatively rare in the western healthcare systems where I have practiced emergency medicine (Aus and UK). I have seen it but not often. Reading some of the early reports about the Hubei response ECMO seemed to be very much available and in common use. Not sure we would be able to match that

think that is something on people’s minds, chimpo. I saw this slightly odd “coronavirus readiness map” in the Daily Express which claimed the US and U.K., along with France and Australia, were the best prepared first world countries, more so than say Germany. I found that counter intuitive tbf.

The initial death rate in Italy was high but I assume that was because it was initially spread through hospitals and thus the first batch of infectees includes a lot of people who were already acutely ill.

If Aylward is right about the paucity of undetected infections, which I’m not saying he isn’t, then I would be interested in the explanation of the relatively high number of cases of people coming out of Italy carrying it. You’re telling me they all had contact with the 400 defected cases, most of whom are nowhere near Milan or the ski resorts?

You’re telling me they all had contact with the 400 defected cases, most of whom are nowhere near Milan or the ski resorts?

 I agree that this doesn’t really add up.

Chimp - noted. There clearly must be some - maybe a lot of unreported cases - but we just dont know the order of magnitude and it might turn out not to be as high as expected. On the other hand that would lead to conclusion it may not be as contagious as feared and might be relatively controllable. Tbh looking at the rest of China I think that is very likely the case - albeit it will come at great economic cost.

Sails - yes - sorry should have explained working. Assumed the pandemic penetration was c30% of population. Which is pretty conservative. 1% of 20m is then 200k. So for every per cent in the fatality rate u r looking at 200K dead.

You are right - doomsters cant have it both ways. But of course it being ‘controllable’ begs the questions with what controls? In China they appear to have it under control - but its taken some incredibly stringent shut downs and changes in behaviour across very large areas. So big economic costs and we are still a way from knowing whether it simply flares up again when controls are relaxed.

If you have intermittent shut downs springing up across the whole global economy to keep a lid on it (and massive changes in personal/consumer behaviours - this is going to be a huge psychic shock) - then there will be profound economic consequences. Which will probably be mostly adverse, at least initially.

I agree your 13:08 is a feasible if not probable scenario. The only thing that will stop it being feasible is the development of a universal antiviral - something that kills all viruses and only viruses, and can easily be produced, distributed and administered. Ideally safe enough to be sold over the counter. That should be possible with 5 years of total war level, Manhattan Project level coordinates global research, and that should now be prioritised. Kill this shit, and other shit like it, with fire.

Another point to not on fatality rate is that Chinas demographics are better than ours. Its possible that fatality rate in UK is ultimately worse die to our older population. (Study i saw removing all other variables and just apply current China fatality rates to our demographic suggests a fatality rate in UK which could be twice China’s. Though clearly thats very artificial as so many other variables -I think we probably have fewer smokers/less pollution which will clearly be better.

The only thing that will stop it being feasible is the development of a universal antiviral - something that kills all viruses and only viruses, and can easily be produced, distributed and administered. Ideally safe enough to be sold over the counter. That should be possible with 5 years of total war level, Manhattan Project level coordinates global research, and that should now be prioritised.

Massive heh

Yes m8 we’ll get right on that can’t believe nobody thought of developing a safe universally effective antiviral in 5 years before now thanks for giving us the idea

Heh - I did kind of think that too, but anon has a point in that we may be about to learn that biosecurity is the biggest challenge facing our global civilisation. In which case it would warrant a new level of massive investment to seek further and better solutions.

Civilisation-ruining plague can get in line with civilisation-ruining climate change, civilisation-ruining artificial intelligence, civilisation-ruining wealth inequality and civilisation-ruining porn habits tbh

If every clever person who is currently researching other shit started researching that instead, we’d get it done. Even if all the clever people currently researching novel ways to blow other people up stopped doing that and started researching the universal antiviral - we’d get it done. And yes I know weapons engineers aren’t virologists but one of the emerging theories of scientific practice is that it is, or may out of necessity become, easier for scientists to retool than is commonly perceived.

Another thing, chimpazoid. The Italian “patient one’l, who needed intensive care, was a very fit man of 38 who ran marathons and played football. His ailment bolsters my belief that doing vigorous exercise is very counterproductive in terms of facing respiratory disease. Big gulpfuls of cold air will inflame the lungs anyway, making them raw and receptive to infection, and if you’ve got the lurgy in your upper respiratory system you’re gulping loads of it down deep into your chest. Moral: any attempts I might otherwise have made at exercise above and beyond a gentle stroll (in any event limited) are suspended until this blows over.

Even if all the clever people currently researching novel ways to blow other people up stopped doing that and started researching the universal antiviral - we’d get it done.

Drifting off the point a bit but I actually don’t agree with this - the proposed universal antiviral would be an incredibly difficult problem (if not actually impossible) and those are not necessarily amenable to simply more and more resources and more and more clever people. If that were the case we would have cured cancer by now.

was every fooking body in Italy last week? fooking everywhere is shut because someone went to Italy. News flash dick heads, the skiing is shit in italy anyway.

You’ll be thinking that the other side of your face when the world needs even more saving from viral doom than it does at the mo, as I’d be ace at public health.

Friend in VN sent me this interview with an Israeli doctor who's been helping coordinate the VN govt's response to Corona: https://www.haaretz.com/israel-news/.premium-what-israel-can-learn-from-vietnam-on-how-to-beat-the-coronavirus-1.8589685

They seemingly have it under control atm, but he concedes there are cases have not been identified, and the control they have is likely to be brief because political pressure has forced the VN govt to reopen their Chinese border.

The thing is with all the people coming back from Italy and “showing symptoms” - a lot of them will be bog standard colds/flus etc. We’ve had 4 people self isolate at work - all 4 have been tested and are negative. They just have winter bugs.